Clinical Validation
Backed by 60+ published clinical studies across multiple clinical areas.
1,200+
Correlations Validated
Against thermodilution, the invasive gold standard for measuring cardiac output.
~2×
More Accurate
Regional Impedance Cardiography (RIC) provides significantly higher accuracy than traditional thoracic impedance.
FDA
Bio-Equivalence
Agreement with thermodilution falls cleanly within FDA bio-equivalence guidelines.
90%
Sensitivity
For detecting previously undetected heart disease compared to common screening methods.
"Effect of routinely tailoring anti-hypertensive therapy to hemodynamic profile in primary care."
The American Journal of Medicine (2026)
Prof. John G.F. Cleland & Prof. Zvi Vered
Hypertensive patients studied across two large U.S. primary care groups.
- 47% Vasoconstriction
- 29% Mixed
- 24% Hyperdynamic
Tailoring therapy to the precise hemodynamic profile was associated with rapid and sustained achievement of BP targets and low rates of MI and stroke.
* Note: This was a retrospective, real-world observational study reflecting routine clinical practice outcomes.
Foundational Evidence
NICaS is built upon rigorous validation studies proving accuracy, reproducibility, and diagnostic power.
Accurate noninvasive continuous monitoring of cardiac output
Gad Cotter et al. proved that NICaS CO measurements are highly accurate compared to the invasive thermodilution gold standard.
Read StudyReliability of wrist-to-ankle electrode configuration
Oscar Luis Paredes et al. demonstrated that the NICaS wrist-to-ankle sensor configuration provides highly reliable and reproducible estimates of cardiac output.
Read StudyDetection of left ventricular systolic dysfunction
Yoseph Rozenman et al. validated the Granov-Goor Index (GGI) as highly sensitive (89%) and specific (96%) for detecting LV systolic dysfunction.
Read StudyBroader Evidence Base
NICaS has been utilized in independently led studies across Cardiology, ICU, OB/GYN, Neonatal, Dialysis, and Pharma.